Search results for "antibody"
Article
Your Protein Purification Questions Discussed
In one of Cytiva´s web chats, ÄKTA™ system users asked questions relating to lab-scale protein purification and ÄKTA systems, which experts answered during a live session.
The expert…
Article
Roadmap Leads to Innovative Biomanufacturing Strategies
Roadmap Leads to Innovative Biomanufacturing Strategies
The Biomanufacturing Technology Roadmap is accelerating innovative manufacturing strategies for biopharmaceuticals.
By Feli…
Article
Reducing Cross-Contamination Risks in Process Chromatography
…d in particular for the production of biologic drug substances with high cytotoxic potency, such as antibody-drug conjugates (ADCs), according to Morelli. In Lundström’s experience, in addition to hi…
Article
Performance of Single-Use Xcellerex™ XDR‑500 MO and XDR‑50 MO Stirred-Tank Fermentor Systems
Domain antibody production in E. coli was used as the model process. Fermentations were performed as fed‑batch processes, with glycerol feed and a two‑stage induction strategy. The presented data …
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
When establishing purification processes for a biosimilar molecule it is important to develop steps that are scalable, selective, and cost-effective.
A cation exchange (CIEX) chromatographic ste…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
mAb production using a Protein A capture step has followed a highly successful synergistic path the last 30 years. There are, however, remaining challenges.
• The increased upstream titers in mA…
Article
From Darwin to Recombinant Fc Multimers
Matthias Germer from Biotest Germany presented a novel polyclonal antibody preparation containing IgM (23%), IgA (21%), and IgG (56%) for the treatment of severe community-acquired pneumonia (sCAP), w…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
The molecule exhibits monoclonal antibody (mAb) behavior, however, with a challenging glycosylation profile and complex tertiary and quaternary structures. Consequently, low product recovery and pur…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
In the following section, a case study of of a monoclonal antibody (mAb) in an IEC model is presented.
Mechanistic modeling for development of an ion-exchange chromatography step to purify m…