Search results for " scalable" in Articles / App Notes
Article
A Plastic Pipeline for Commercial Bioprocessing?
“Some initial challenges involved proving that single-use manufacturing is scalable to commercial scale. There is enough evidence now that single-use technology is suitable for commercial-scale bioman…
Article
Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography
Early adopters are benefiting from lower costs and increased productivity.
By Cynthia A. Challener
Tashatuvango/Shu…
Article
Understanding Validation and Technical Transfer, Part I
The clinical formulations must be scalable to commercial production, retaining their effectiveness and safety attributes. Commercial production processes must be robust and reliable to ensure consiste…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…
Article
Going Small to Achieve Success on the Commercial Scale
…t achieved between the bench and commercial scales, and therefore, model processes are not perfectly scalable. The causes, according to Jorjorian, may not relate directly to the process, but can be a…
Article
Taking a “Development-by-Design” Approach to Cell Therapies
Jun 15, 2015
By Agnes Shanley
BioPharm International eBooks
Volume 28, Issue 13
Whether outsourcing or developing cell therapies in-house, success demands a focus on quality, c…
Article
Modular Manufacturing Platforms for Biologics
Other benefits of pods include compact ductwork (which lowers the operating costs); they can be sanitized robustly and therefore can run in multi-product modes; and they are easily scalable, so instal…
Article
Q&As with Industry Leaders
…s Development & Strategy, Cytiva
Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
Anki Magnusson, Staff Research Engineer, Protein and Viral Pro…
Article
Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Sterility must be assured for all biologic drug products. Terminal sterilization achieved via treatment with heat, radiation, or certain chemicals (vaporous hydrogen peroxide, vaporous peracet…
Article
Alternative solutions to separate AAV full and empty capsids using anion exchange
Adeno-associated virus (AAV) is the main vector for gene therapy and there is need for scalable, cost-efficient, and robust chromatography-based purification. Key for a successful process are …