Search results for " scalable" in Articles / App Notes
Article
Witnessing Major Growth in Next-Generation Antibodies
Including next-gen antibodies in pharma pipelines is considered essential for future success.
By Cynthia A. Challener
Next-generation antibodies are designed to be more specific and are ofte…
Article
Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
Article
Generating a Fully Processed Antibody
Both the cell lines and culture processes were easily scalable to larger bioreactors while maintaining good antibody titers and the consistent tag conversion that is required for this unique site-spec…
Article
Continuous Processing for the Production of Biopharmaceuticals
The authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platf…
Article
Selecting the Right Viral Clearance Technology
The selection of robust, highly scalable methods that are not affected by variations in feedstocks and consumables is essential for achieving reliable and consistent processes in terms of both their v…
Article
Antibody Fragments and Their Purification by Protein L Affinity Chromatography
…und Protein A affinity chromatography have proven to be fast, efficient, robust, cost-effective, and scalable. Most antibody fragments lack Fc and suitable affinity for Protein A. Adapting proven ant…
Article
Fermentation for the Future
In addition, the system is not limited to the production of small proteins and peptides, as is the case with microbial fermentation, and it is also readily scalable, according to Sutro.
About the …
Article
Ligand-Binding Assays and the Determination of Biosimilarity
During biosimilar development, it is necessary to demonstrate that the physicochemical properties, efficacy, and safety (e.g., immunogenicity) of the biosimilar are similar to those of the …
Article
Optimizing Resin Performance with Disposable Chromatography Solutions
Although the initial uptake of single-use chromatography solutions has been relatively slow, an increased need for higher-capacity resins and the demand for smaller batches has made disposable chrom…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
In this study, the authors evaluated different approaches to prepare highly concentrated feed media for fed-batch Chinese hamster ovary cell culture. By raising the pH or by adding surfactants, the fe…