Search results for " Mab"
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
al, MAbs 9, 1349–1359 (2017).
15. S. Vainauskas, et. al, Sci. Rep. 8 (1), 9504 (2018).
16. T. Walsh, et. al, Bioinformatics online, DOI: 10.1093/bioinformatics/bty681, Aug. 7, 2018.
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Article
Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…
Article
Cleaning Protein A Resins with 1 M NaOH
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Article
Reducing Cross-Contamination Risks in Process Chromatography
MilliporeSigma, for instance, offers single-use chromatography membranes designed for high mAb throughput that allow the high loadings often obtained in stainless-steel facilities.
Morell…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Article
Downstream Processing for Cell-Based Therapies
As with the production of mAbs, significant research and development for CGT processes has focused on the intensification of upstream production. For example, several studies have investigated the opt…
Article
Single-use Bioreactors Have Reached the Big Time
“Examples include traditional vaccines and blockbuster [monoclonal antibody] (mAb) biologics (>2 metric tons of mAb per year); in these cases, single-use bioreactors might not be the most efficient pr…
Article
Walk Away and Do More Screening Preps
Learn how an ÄKTA pure protein purification system can be modified to increase throughput of mAb purifications and decrease hands-on time.
Article
Fed-batch supplements to boost cell culture performance
This application note demonstrates the enhanced performance of commonly used cell lines for MAb production when supplemented with HyClone™ cell culture supplements. Cultures of Chinese hamster ovary (…
Article
Best Practices in Qualification of Single-Use Systems
Figure 1: Typical mAb manufacturing process.
The implementation of SUS usually starts with development of the user requirement specification (URS). Typically, the development engineers at biophar…