Search results for " protein"
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
SPR is a rapidly emerging tool for studying ligand binding interactions with membrane proteins, which are the major molecular targets for biopharmaceutical products (6). In SPR, one of the interactant…
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Managing Residual Impurities During Downstream Processing
Challener
Manufacture of protein and other biologic drug substances via cell culture or fermentation occurs with the natural, simultaneous production of other unwanted materials, particularly host-…
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Q&As with Industry Leaders
…lobal Product Manager, Monoclonal Antibody Polishing, Cytiva
Top challenges in recombinant protein purification process development
Jeanne Linke Northrop, BioPharm International
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The Development and Application of a Monoclonal Antibody Purification Platform
Such increases could change the characteristics of the cell culture broth, leading to higher levels of product-related heterogeneous proteins (aggregates, degradation products, processing variants) an…
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Milestones and Moderate Progress in 2012 Drug Approvals
The recombinant protein displays terminal mannose residues in its glycocomponent, facilitating direct product uptake by macrophages (the target cell type) via cell surface mannose receptors.
Int…
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Top Tips for Successful Development of Antibody Chromatography Processes
We've seen this specific drug class continue to reshape medicine, right? It's so amazing what we've learned about these molecules, their potential, the different ways to leverage these proteins. I'm r…
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Optimizing your Cell Culture Process to Improve Productivity
It could also be used to analyze monoclonal antibody protein quality by examining the parameters, supplements, and feed timings, which may help increase the quality of the protein being produced in cu…
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Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
…it's really at because every sample that has to go to an analyst, whether it's a small molecule or a protein or a biologic, takes time to run on a system. It takes a dedicated person to run that samp…
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Tips for Purifying and Analyzing Cryo-EM Samples
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Cryogenic electron microscopy (cryo-EM) provides possibilities to determine structures for more challenging proteins, such as membrane proteins and larger protein compl…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Studies and rankings showed that aggregation and Protein A fragmentation were crucial CQAs, Adkins said. Upstream, the most important CQAs include glucose concentration and cell mobility; downstream, …