Search results for " antibodies"
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Advances in Engineering of Protein-Based APIs
Today, monoclonal antibodies (mAbs) have become one of the predominant forms of protein-based biopharmaceuticals, with humanization and fully human monoclonals contributing to their increasing success…
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Get to know: mAb variants - eLearning
Cytiva has published an interactive course that gives an overview of monoclonal antibodies (mAbs) and current variants used and developed in academia and industry.
Key learnings are:
- Structure…
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Emerging Therapies Test Existing Bioanalytical Methods
In addition, many of the viral vectors may react with antibodies already present in animals and humans. To prevent these pre-existing antibodies from interfering with the program, it is recommended to…
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Process Development: What May Lie Ahead in 2018?
Aligning with this news, Process Development Forum readers showed strong interest in an article discussing next-generation antibodies, which are often more potent and more specific than traditional mo…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
For traditional mAbs, protein A chromatography is used to capture antibodies. Depending on the structure of the target antibody and the impurity profile, other affinities, like protein L or variants o…
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Re-use of Protein A Resin: Fouling and Economics
Its high specificity for the Fc region of antibodies is the primary reason for its dominance as the affinity ligand of choice in numerous immunological and purification applications (1). Specificity o…
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Purification strategies for antibody-derived entities: bispecifics and fragments
Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for antibody variants to simplify protocols and improve purity and yield. The safety and efficiency requirement of …
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Get Started: Purification of mAb Variants - eLearning
The success of monoclonal antibodies (mAbs) as therapeutics and the multi-domain structure of antibodies has made it possible to create antibody variants, such as bispecific antibodies (bsAbs)…
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Process Chromatography: Continuous Optimization
Monoclonal antibodies (mAbs), which today account for approximately 50% of the total revenues of all biopharmaceuticals according to David Westman, global product marketing manager for Cytiva, are typ…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Therapeutic proteins, peptides, and antibodies have emerged as highly effective modern medicines for numerous diseases and disorders (1). Therapeutic monoclonal antibodies (mAbs) represent a rapidly g…