Search results for " membranes" in Articles / App Notes

Article Tips for Purifying and Analyzing Cryo-EM Samples
Click here to read more >> Cryogenic electron microscopy (cryo-EM) provides possibilities to determine structures for more challenging proteins, such as membrane proteins and larger protein compl…

Article Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars A major advantage of SPR-based analysis is its ability to estimate the association and dissociation rate constants, an …

Article Challenges in Cell Harvesting Prompt Enhancements
…niques: centrifugation, microfiltration, depth filtration, and filtration through absolute pore size membranes (1). A key challenge in cell harvesting is how to deal with higher cell densiti…

Article Reducing Cross-Contamination Risks in Process Chromatography
MilliporeSigma, for instance, offers single-use chromatography membranes designed for high mAb throughput that allow the high loadings often obtained in stainless-steel facilities. Morell…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
The authors review how media components modulate the quality of monoclonal antibody products.  By Anurag Rathore, Rajinder Kaur, Dipankar Borgayari  Recombinant protein products have…

Article Process Chromatography Selection for Downstream Processing Applications
Industry experts discuss best practices for selecting a separation technology. By Caroline Hroncich Process chromatography has changed significantly since it was first introduced to the biop…

Article Tools for Continuous Bioprocessing Development
Could perfusion microbioreactors bring more agility to biomanufacturing? By Rajeev J. Ram In semiconductor manufacturing, for example, a thorough understanding of process variation allows co…

Article Selecting a Comprehensive Bioburden Reduction Plan
Process maps and risk assessments are among the valuable tools operators can apply to reduce the risk of microbial contamination. By Randi Hernandez There are multiple variables to consider …

Article Trends in Downstream Bioprocessing
Many of the same challenges that have plagued the industry over the past few years continue: • Cost of chromatography materials • Lack of single-use (disposable) options • Cost of membrane…

Article Regulatory Challenges in the QbD Paradigm
The authors demonstrate how an integrated model is helping to achieve regulatory flexibility. This article is part of a special section on biopharmaceutical trends. With the dawn of the 2…

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