Search results for " patients" in Articles / App Notes
Article
Balancing AAVs Versus LLVs
Knowledge of adeno-associated variant's infection pathway is based on only a few serotypes. The prevailing understanding is that serotypes bind to different, or have differential affiniti…
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Host cell protein quantitation using ELISA
Host cell proteins (HCPs) produced by cells during biologic manufacturing must be removed from the final product to protect patients. However, it’s challenging to detect HCP, and this step c…
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Future-proof your AAV process with a complete producer cell line – just induce and grow
Stable producer cell lines helped to make mAb therapies the powerhouses they are today. To deliver on the promise of AAV-based gene therapy for prevalent diseases, we need similar technology. …
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Expanding the Emerging Therapeutic Horizon
However, through new opportunities it is hoped that greater benefits to patients, particularly those in undertreated populations, will be achieved.
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Process Development and Control for New Modalities
…es in the pipeline and thus ensure that safe and effective novel treatment options can be brought to patients more quickly.
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Top Process Development Trends for 2022 and a Look into 2023
More than half of these approvals were for patients with rare diseases such as acid sphingomyelinase deficiency (an inherited disease that affects the body’s ability to metabolize fat) or generalized …
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Developing a Robust Bioprocess Using Mechanistic Models
Therefore, manufacturers have to design, implement and maintain measures to ensure that the bioprocess constantly delivers a high-quality product and patients are never at risk. The robustness of the …
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Enhancing Resins Addresses Purification Concerns
Christoph Burgstedt/Stock.Adobe.com
Enhancement of resin technology can improve the ability of chromatography to purify the growing landscape of increasingly complex biomolecu…
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Track-and-Trace Progress Benefits Supply-Chain Security Efforts
Since the COVID-19 pandemic struck, there has been little news of serialization breakthroughs, as manufacturers and their supply partners have focused on getting new therapeutics and vaccines to patie…
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Updating Viral Clearance for New Biologic Modalities
Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.
By Feliza Mirasol
Ensuring viral clearance (i.e., removal) in downstream purification has becom…