Search results for " vaccines"
Article
Going Viral
Manufacturing viral vector-based therapies such as vaccines and gene and cell therapies is complex, but a new manufacturing solution helps solve those challenges. The new KUBio BSL-2 solution for vira…
Article
Reducing Cross-Contamination Risks in Process Chromatography
Preferred target molecules
A variety of biologics benefit from the use of disposable technology in their production, from monoclonal antibodies (mAbs) and recombinant medicines to vaccines and…
Article
Process Chromatography: Continuous Optimization
“This resin chemistry is beneficial for the separation of large molecules, such as viruses, vaccines, and immunoglobulin M,” says Westman.
Biosimilars and other challenges
The increased trend towa…
Article
Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
A majority of cell lines commonly used for viral vaccine production are anchorage-dependent and require expansion on solid surfaces. Here, we describe different approaches for the cultivation of Ver…
Article
Efforts Accelerate to Streamline Postapproval Change Process
WHO recently issued guidelines on procedures and data requirements for changes to approved vaccines (4). The agency also is developing guidelines for dealing with variations in prequalified products, …
Article
Fluid Handling in Biopharma Facilities
For example, flexibility is key in the case of manufacturing facilities that have to deal with multi-products for seasonal vaccines or pandemic response vaccines.
Hutchinson (Parker domnick hunter…
Article
Detecting Protein Aggregates and Evaluating their Immunogenicity
(2) on forced degradation studies in vaccines have helped evaluate the propensity of a product to aggregate at various points in the manufacturing process.
Higher concentrations of a protein formu…
Article
Concentration and Diafiltration of Cell-Derived, Live Influenza Virus Using 750 C Hollow Fiber Filter Cartridge
Cross flow filtration (CFF) is a technique extensively used in vaccine production and particularly in influenza vaccine manufacturing. In contrast to normal flow (dead-end) filtration (NFF), the fee…
Article
Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Scaling considerations
Scaling itself does not necessarily increase the risk of losing sterility during viral-vector manufacturing, particularly for high-volume, low-titer products such as vaccines…