Search results for " equipment"
Article
Tools and Processes for Mature and Emerging Therapies
In April 2019, at the INTERPHEX trade show in New York City, vendors of bioprocessing equipment and materials announced improvements to existing platforms, added options for upstream and downstream sy…
Article
Scaling Up Novel Therapies
Chromatography and filter manufacturers have developed scalable and reproducible low-volume mimics of their industrial-scale equipment, which allow more accurate scale-up work than ever before, he say…
Article
A Plastic Pipeline for Commercial Bioprocessing?
Lower capital costs for facilities and equipment, lower operating costs, smaller equipment footprints, lower overhead costs, flexibility of system configurations, faster changeover times, the reductio…
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
For example, our studies have shown rather consistent incremental increases in upstream cell culture titers over the past three decades; and it took well over a decade for single-use equipment to atta…
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
… have lower costs, smaller footprints less support infrastructure, but they still have some reusable equipment. The key benefits are derived from decoupling process equipment from building (i.e. havi…
Article
Automating Bioprocesses
By Jennifer Markarian
Both upstream and downstream biopharmaceutical processes have conventionally used stainless-steel equipment, but use of single-use systems (SUS) is becoming more established.…
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
…ures to toxic contaminants, metabolic waste products, or leachables from polymers used in single-use equipment and flexible packaging films (24, 25). It has been difficult to identify functionally eq…
Article
Automation Trend in Fill/Finish Reduces Contamination Risk
Because aseptic filling requires close coordination and involves complex interaction between personnel, sterilized product, the fill/finish equipment system, the cleanroom—including support facilities…
Article
Understanding Validation and Technical Transfer, Part I
“In its simplest form, a process is a blending or a transformation of inputs such as people, materials, equipment, methods, and environment into outcomes. Some of these inputs do the transforming and…
Poster
Scale-up and process economy calculations of a dAb purification process using ready-to-use products
In addition, process economy of using ready-to-use equipment and ready-made buffers versus using reusable equipment and in-house prepared buffers was compared. A three-step dAb purification process wa…