Search results for " equipment"
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Sterilization Trends for Single-Use Consumables
X-Ray Sterilization of Single-Use BioProcess Equipment, Part 1: Industry Need, Requirements & Risk Evaluation. Technical Guide, May 17, 2021. https://www2.bpsalliance.org/forms/store/ProductFormPublic…
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Under pressure: exploring root causes of leaks in single-use mixers
But efficiency isn’t just about what your equipment can do – it’s also about how well it performs and scales up. Equipment failures in large-scale bioprocess can be costly in terms of material loss an…
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Using Digital Twins to Model Process Chromatography
By Jennifer Markarian
A digital twin is a model of a process that allows process development experiments to be run in silico—on a computer—rather than on actual lab or manufacturing equipment. Alt…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
The fixed-bed principle allows for cells to be grown to much higher densities per unit volume of vessel than they would be in a stirred tank bioreactor, which results in a much more compact equipment …
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Cytiva Introduces the Xcellerex Automated Perfusion System
The APS system comes equipped with filter switching, liquid management, and cell bleed to reduce risk of human error and increase process robustness.
Cytiva announced on Sept. 16, 2020 that it i…
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Eliminating Residual Impurities Starts with a Strategic Plan
They can be derived from the host cell or the product itself, media components, surfactants, virus inactivation agents, inorganic or organic contaminants from permanent and single-use process equipmen…
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Good Manufacturing Practices: Challenges with Compliance
Muzzin (Emergent): One industry challenge is the need to continuously strike a balance between providing continual supply of products to the market with the approved facility and/or equipment while al…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
This higher productivity enables a scale-out approach with multiple same-size bioreactors rather than scaling up to larger bioreactors for commercial production, meaning that the same equipment and pr…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
However, chromatography has been the last purification stage to move into disposable equipment. Although its use is growing downstream, it is still limited. In addition, the industry’s adoption of pre…
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An Analytical Approach to Biosimilar Drug Development
Advances in equipment and software have also led to improvements in automation, both in the laboratory and in data processing. Automation has been key in allowing ligand-binding assays to meet the int…