Search results for " detection"
Article
From Darwin to Recombinant Fc Multimers
Topics from a Darwinistic viewpoint on how business models are evolving in the Life Science industry to breakthrough research data from Momenta Pharmaceuticals on a recombinant trivalent Fc protein …
Article
Being Thorough When Transferring Technology
Communication and taking the time to develop the process are key to successful transfer and scale up of biologics.
By Susan Haigney
Editor's note: The following is an extended version of the…
Article
Witnessing Major Growth in Next-Generation Antibodies
Including next-gen antibodies in pharma pipelines is considered essential for future success.
By Cynthia A. Challener
Next-generation antibodies are designed to be more specific and are ofte…
Article
Single-use Bioreactors Have Reached the Big Time
The implementation of Sartorius’ integrated non-invasive biomass sensor in our rocking motion bioreactor gives real-time data on cell health and enables early fault detection, and is a major step towa…
Poster
Collaborating to address the bioburden challenge
Bacteria and their byproducts can negatively affect the safety and potency of a biopharmaceutical drug. At a minimum, bioburden contaminations lead to reduced productivity as a result of lost batche…
Article
Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The detection wavelength was 280 nm. The column equilibration (65 minutes) and sample elution (35 minutes) was done with the mobile phase (50 mM sodium citrate, 450 mM sodium chloride, pH 6.5) run at …
Article
Generating a Fully Processed Antibody
At the time, a high-throughput detection method for FGE expression was not available; therefore, clones were selected based on the number of copies of the FGE gene that were inserted into the genome o…
Article
Affinity chromatography Handbook: Vol. 2 Tagged Proteins
The advantages of using a protein/peptide tag fused to the recombinant protein to facilitate its purification and detection are now widely recognized. In some cases, tags may improve the stability and…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
Use of a subspace model is a viable method to characterize process space variables and optimize process performance.
By Colin Jaques, Daniela Lega
Over the past decade, two improved capabili…
Article
Selecting a Comprehensive Bioburden Reduction Plan
…ing and sanitization requirements, establishment of alert/action levels, selection of monitoring and detection methods, operator training requirements, and quality system oversight.
BioPharm: Wha…