Search results for " growth" in Articles / App Notes
Article
A Closer Look at Affinity Ligands
Another affinity matrix also provides high affinity for recombinant human growth hormone (hHGH) by using an immobilized 14 kD single variable domain of heavy chain (VHH) antibody that is recombinantly…
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
As you mentioned with the perfusion reactors, that's an area where we've seen a lot of growth in the last five to 10 years, because people are generating large quantities of cells in a very short peri…
Article
Gene Therapies Push Viral Vector Production
In addition, the growth factors need to be continuously and manually added/replenished in the medium. This cumbersome process leads to an increase in the chances of errors.
• Cell expansion …
Article
What’s New in Upstream Technologies
According to the company, the bioreactor offers an increase of the surface/volume ratio compared to conventional technologies, with 10 m2 growth surface in 1.8-L working volume and 30 m2 growth surfac…
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Supply Chain Challenges for Single-Use Systems
The demand for customized systems and the overall growth of demand for SUS add to the pressure to improve supply.
Most SUS are currently made in the United States and the European Union, but sup…
Article
Platform Technologies Improve Protein Expression
…tein expression ranging from the choice of cell line, expression plasmid design, cultivation medium, growth conditions, equipment, scalability, stability, and matching purification capability, to nam…
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Modeling Bioreactor Performance
One specific application noted by Fenge is relevant to cell growth on carriers (e.g., in the vaccine and regenerative medicine sectors). “CFD modeling is used to understand the shear forces in the dif…
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Biosimilars: Making the Switch Comes with Challenges
With approximately 20 new biosimilars authorized for marketing across the EU since 2006, prescribing of the drugs is increasing at a rate of 11% a year, similar to the worldwide growth rate, according…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
… to be approximately 30 PD including the cell age of a WCB, seed train, and bioreactor expansion and growth in the production vessel. Extra cell culture passages in the cell expansion stages are adde…
Article
Antibody Production in Microbial Hosts
One of the most important challenges is predicting the manufacturing behavior of cell lines at early stages and selection of clones with appropriate growth characteristics. Process improvements have g…