Search results for " single-use"
Article
The Outlook for CMO Outsourcing in 2019
The industry is starting to see a major trend for CMOs adding 1000–2000-L single-use bioreactor process lines for commercial manufacturing as products currently in development manufactured with single…
Article
Scaling Up Novel Therapies
Cell culture improvements were followed closely by small-scale single-use technologies. As a result, on the bacterial side, developers can now go into production using 100- to 300-L single-use reactor…
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Optimizing Late-Stage and Commercial Cell-Culture Processes
In addition, development of intensified processes and integrated continuous processing (with single-use technology and sensors/control) have also contributed to increasing titers, maintaining consiste…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Also unpredicted 15 years ago was the rate of adoption of single-use devices. While 15 years may seem a long adoption cycle, in the bioprocessing industry, where regulators are involved in most decisi…
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Speed and Flexibility Are Dual Goals for Biopharma Operations
Modular processing equipment and single-use technologies are positioned for flexible production operations and replication in other locations.
For example, FujiFilm Diosynth expanded its contract …
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Price pressure on biosimilars has driven trends toward more cost-effective manufacturing processes, such as single-use technologies, throughout the biopharmaceutical industry. One counterintuitive tre…
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Technologies and Practices Must Evolve to Meet Demand
Sampling systems, single-use systems, and sterile sampling received “poor” or “inadequate” grades from more than 19% of the respondents.
Survey participants also rated how the level of inno…
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Trends in Downstream Bioprocessing
In addition, the recent increase in upstream single-use technologies has created pressures on DSP operations to keep up.
DSP remains one of the most crucial and talked-about areas of biophar…
Article
The use of Xcellerex™ mixing system as slurry tank when packing chromatography columns
The single-use system eliminates the hassle of time-consuming and costly steamin-place, clean-in-place, and cleaning validation procedures. The result is an efficient processing and rapid batch-to-ba…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Scaling strategies in STRs are well established though, and single-use options exist from the millilitre scale up to 6000 L (7).
Recent technological innovations provide substitute solutions. The …