Search results for "Mabs" in Articles / App Notes
Article
How to Address Bioburden Challenges: Insights and Tips
Another important area where suppliers can contribute is sanitization and storage procedures for protein A chromatography resins, which are widely used to purify mAbs.
Learn more about insights an…
Article
Fusion Proteins Pose Manufacturability Challenges
“Overall,” he adds, “a fusion protein will often have liabilities that will need to be addressed by more process development than would be typically needed for monoclonal antibodies (mABs), which are …
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Mechanistic modeling for development of an ion-exchange chromatography step to purify mAbs
In this section, the authors provide a step-wise method to build an ion-exchange mechanistic model …
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
To date, the majority of monoclonal antibodies (mAbs) have generally targeted a particular antigen; however, there are several additional antibody formats currently in the development pipelines of pha…
Article
SEC in the Modern Downstream Purification Process
Mar 01, 2015
By R. Christopher Manzari, J. Kevin O'Donnell
BioPharm International
Volume 3, Issue 28
Since the introduction of commercial chromatography resins approximately six de…
Article
The Bullish Outlook for Biosimilars
To grasp the potential impact that mAbs will have on the biosimilar market, there are more than 600 mAbs currently in development for oncology alone (10). Together with the fact that insulin biosimila…
Article
Milestones and Moderate Progress in 2012 Drug Approvals
First gene therapy and plant-based expression vector products approved in 2012.
In terms of product approvals, the past year can be considered reasonably successful. Twelve biopharm…
Article
Address the complexity of protein characterization
Since the FDA approved the first monoclonal based therapy in 1985, mAbs have had significant clinical success and have been used to provide effective treatment for a range of diseases. Durin…
Article
Downstream Process Developers: What are Your Antibody Processing Challenges?
We're asking PD scientists to tell us about their biggest challenges developing downstream processes for mAbs and their variants.
Take this short, anonymous survey to share your insights. We’ll …
Article
Webinar: Intensifying downstream bioprocessing with continuous technologies
Webinar on June 20, 2024
Significant operational improvements can be achieved by intensified continuous processes compared to standard batch processes.
In this webinar we will explor…