Search results for "buffer" in Articles / App Notes
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Readers also wanted to dig into other tools for process intensification such as buffer management. One hot article answered two commonly asked questions about in-line buffer preparation, which …
Article
Driving Change in Biomanufacturing
The large buffer volumes required for biomanufacturing can be a bottleneck, especially when scaling up. Just-in-time buffer preparation can be the solution. In this blog, we discuss the two most commo…
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Next, if known, specify the buffer and media requirements of each unit operation step in the production process, including whether any solutions require special handling (e.g., 70% ethanol), if steps …
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The properties of octylamine ligand, allowing for binding of impurities over a broad pH range, high salt concentrations, and in various buffer compositions, enable the use of Capto Core 700 chromatogr…
Article
Connected Inline Conditioning for Better Process Efficiency
This automated the buffer preparation process, saving time, space, and costs.
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Article
Get Confident: Inline Conditioning Control Modes
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In this course, you will learn how to use the control modes of the BioProcess Inline Conditioning (IC) system used for buffer preparation. The control modes are the s…
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Addressing the Complex Nature of Downstream Processing with QbD
For this kind of step, it is important to understand the process parameters such as load ratio, buffer ranges, as well as resin ligand density when developing the control strategy,” says Malmquist.
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Using Multiple Techniques in Biosimilar Analysis
Similarly, the formulation buffer may include excipients that cause some techniques to fail, or the formulation concentration of the API may be too low to detect using certain techniques. These occasi…
Article
From Darwin to Recombinant Fc Multimers
Joakim Lundkvist from Cytiva presented data from a real-life case study with a plasma fractionator on buffer management, which show significant savings in CAPEX, tank space, floor space, and number of…
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Downstream Processing for Cell-Based Therapies
A biological safety cabinet usually is needed for the subsequent resuspension step, which involves discarding spent medium and resuspending in a suitable buffer. This process may be repeated multiple …