Search results for "Protein"
Poster
Columns up to 1600 mm in diameter packed with protein A chromatography medium using axial mechanical compression
Axial compression allows for optimally packed beds also in the large-scale chromatography column range. Different methods have been developed to pack a broad range of chromatography media (resins) i…
Resource
Halle Conference on Recombinant Proteins, Halle, Germany
Feb 19-20, Halle, Germany
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
In the future, mAbs may represent a smaller percentage of the pipeline as portfolios concentrate more on development of antibody fragments, nanobodies, biosimilar protein therapeutics, conjugated prot…
Article
Impurity Testing of Biologic Drug Products
“On the other hand, the impurity may exaggerate or enhance the therapeutic protein’s bioactivity in an uncontrolled way, leading to adverse events. Some impurities (especially host cell proteins) may …
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
Of these, mAbs comprise large, multi-domain proteins that require complex machinery for proper protein folding, assembly, and post-translation modifications. These modifications can profoundly affect …
Article
Modeling the Degradation of mAb Therapeutics
Proteins pose stability risks
Monoclonal antibodies are currently the leading class of protein therapeutic molecules due to their ability to treat a wide range of lethal and life-threatening disea…
Article
Generating a Fully Processed Antibody
These include molecules such as virus-like particle (VLP) vaccines, proteins that require cleavage, or other additional post-translational modifications not typically performed by Chinese hamster ovar…
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A Closer Look at Affinity Ligands
The most common example in the realm of bioprocessing is Protein A, which has an extremely high affinity for some immunoglobulin molecules. Other examples include antibody/antigen, enzyme/substrate, a…
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Elucidating Biosimilars Characterization
Proteins produced in different mammalian cell lines, or under different environmental conditions, may be expressed with subtle but important differences with respect to characteristics such as glycosy…
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Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
Thermal analysis of protein samples was performed by modulated differential scanning calorimetry. The freezing rate in a single freeze-thaw cycle had negligible impact on protein aggregation when fast…