Search results for " information"
Article
Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
Practical information is given as a guide towards obtaining the desired results.
Download the handbook
Article
Resolving a bottleneck in screening and characterization of recombinant antibody fragments using Biacore 4000
Kinetic analysis at different temperatures provided additional information on the temperature stability of the selected fragments with respect to affinity. Chimeric chicken/human Fab fragments were sc…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
This information is summarized in Table I.
Table I: Cell-detachment methods with potential impact on biopharmaceutical applications.
In cell scraping, a rubber or plastic spatula is…
Article
A Q&A With Jeff Carter on Trends in Single-Use Technologies
This development will lead to the increasing availability of high quality single-use material information which, in turn, will provide greater technical insight to process performance. This will help …
Article
Going Small to Achieve Success on the Commercial Scale
…se of design-of-experiment (DoE) methodology minimizes the required number of runs and maximizes the informational output, it is impractical to conduct such characterization experiments at full scale…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
By collapsing the two dimensions with the least useful information (i.e., height and time), a useful navigational map can be made in a two-dimensional subspace.
A subspace approach can…
Article
Selecting the Right Viral Clearance Technology
…ure good clearance, but the development of viral clearance studies are often required to obtain this information,” Remington says. She adds that mapping the design space of a process step for viral c…
Article
Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
An assessment of mycoplasma contamination in the National Center for Biotechnology Information Sequence Read Archive conservatively found that 11% of projects were contaminated (19). The authors estim…
Article
Selecting a Comprehensive Bioburden Reduction Plan
Process maps and risk assessments are among the valuable tools operators can apply to reduce the risk of microbial contamination.
By Randi Hernandez
There are multiple variables to consider …
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
By studying multiple factors simultaneously, DoE allows a maximum amount of information from the minimum number of experiments. Objectives such as screening, optimization, and robustness testing are s…