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Article Strategizing for Rapid Changeovers in Biologics Manufacturing
“In addition,” he says, “use of analysis of the data collected by the manufacturing execution system can provide information about trends during different changeovers and their possible impacts on the…

Article Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Biomanufacturing: Demand for Continuous Bioprocessing Increasing But are innovations sufficient to increase adoption? CMOs are demanding better continuous bioprocessing options.   …

Article High-Throughput Process Development in Biopharma
During early process development, high-throughput process development (HTPD):  • Shortens development time • Increases the amount of information available • Enables reduction of sample a…

Article Improving Upstream Predictability
Lonza is also moving to the use of electronic batch records to pull information from various systems and build a fully integrated, transparent manufacturing network, says Mohindra. Other eff…

Article Mapping a Route for Cell and Gene Therapy Process Development
This results in part due to the complexity of the product, but also due to a lack of analytical tools that can provide relevant information with sufficient sensitivity. There is also a need for approp…

Article Quality by Design in Biotherapeutics Purification: Understanding and Addressing Sources of Process Variability
This white paper summarizes information around resin variability, serving as a reference and providing support for developing robust purification processes for biopharmaceuticals.

Article Efficient and Scalable Buffer Preparation
It also explains how ÄKTA avant™ can be used to obtain molar recipe information instead of doing tedious and time-consuming titration in the laboratory. Click HERE to read the article

Article Using Software in Process Validation
For example, if there are 10,000 lines running on a controller, the system will simply highlight what is changed and will send that information to an email distribution list so that a manager or ­deci…

Article Best Practices for Selecting a Top-Quality Cell Line
Bioinformatics analysis may help in getting genetic/epigenetic information that could offer insights into issues with protein production or cell stability in advance, agrees Cai. “Transcriptomi…

Article Tools and Processes for Mature and Emerging Therapies
Focus on data Capturing process data and applying that information to control process operations was a major theme at INTERPHEX. Notable announcements include the application of artificial i…

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