Search results for "fermentation"
Article
Performance of Single-Use Xcellerex™ XDR‑500 MO and XDR‑50 MO Stirred-Tank Fermentor Systems
Fermentations were performed as fed‑batch processes, with glycerol feed and a two‑stage induction strategy. The presented data was collected as foundational single‑use fermentation work, and can…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
…ography carried out in 96-well plates, and how this work could support optimization of the upstream fermentation process.
Formulation and Frontiers
At previous HTPD conferences, there wer…
Article
Single-use Bioreactors Have Reached the Big Time
Cytiva, meanwhile, recently introduced single-use technologies for microbial fermentation. The system is designed to accommodate the demands of microbial cultures, including mass transfer, mixing, and…
Article
Modeling Bioreactor Performance
Challener
Bioreactor design, including the geometry of the tank and impeller and the locations of inlets, has a direct impact on the performance of cell-culture and fermentation processes. Modelin…
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
Figure 1: Potential exposure of media components made by fermentation. Diagram of a typical manufacturing process for recombinant insulin, a media component made by fermentation. This diagram helps il…
Article
Biopharma in 2015: A Year for Approvals and Innovations
A paper on process economic comparison between fermentation in single-use versus stainless steel equipment on PDF was well received.
This year, PDF will continue to report on drug approvals, innova…
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Host-Cell Protein Measurement and Control
Recombinant therapeutic proteins are usually produced by genetically-modified prokaryotic or eukaryotic host cells using cell culture/fermentation technology (2). Genetic engineering allows the host c…
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Outsourcing Trends in Biopharmaceutical Manufacturing
The results over the past 10 years tell show that outsourcing is not only increasing across traditional systems including mammalian cell culture and microbial fermentations, but also across newer syst…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
These small single domain antibodies can be easily captured from fermentation broth using Protein A since they can be derived from the VH3 IgG gene family (35, 36). Subsequent downstream purification …
Article
Eliminating Residual Impurities Starts with a Strategic Plan
For example, he notes that if a platform drug substance downstream process has shown for different platform molecules that a supplement added during fermentation can be depleted to a satisfactory leve…