Search results for " filtration"
Article
Improving Upstream Predictability
Univercells has leveraged process intensification in a new single-use bioreactor design that features a structured fixed-bed bioreactor connected to an automated tangential flow filtration concentrato…
Article
Mapping a Route for Cell and Gene Therapy Process Development
In addition, the downstream processing steps can vary significantly depending on the product specifications and available downstream technologies, such as tangential flow filtration, counter-flow cent…
Article
New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
Article
Addressing the Complex Nature of Downstream Processing with QbD
During downstream processing, virus inactivation, virus filtration, and chromatography steps are performed. Malmquist believes designing viral safety into processes from the beginning is of “high valu…
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Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…
Article
Analytical SEC: How Does Back Pressure Relate to Resolution?
High resolution in HPLC is not achieved by applying back pressure to the column. Let’s straighten out what really helps you achieve high-resolution analytical SEC data.
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Article
Protein Analysis with Size Exclusion Chromatography
Size exclusion chromatography (SEC) is widely used in several different analytical applications from basic research to quality control of biotherapeutics. This white paper presents fundamentals abou…
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Achieving Process Balance with Perfusion Bioreactors
Alternating tangential flow (ATF) filtration technology (developed by Refine Technology, now Repligen) is commonly used.
For perfusion processes used to manufacture chimeric antigen receptor (CAR)…
Article
Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production.
Due to the diversity of viruses, platform solutions are challenging to implement e…
Article
Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…