Search results for " high-throughput" in Articles / App Notes
Article
Advances in Engineering of Protein-Based APIs
Similarly, miniaturization and high-throughput versions of protein assays will reduce analysis times and enable exploration of wider design spaces. Stevens points to nanofluidic characterization assay…
Article
Miniaturization to Become Even More Successful
The industry has turned to high-throughput process development (HTPD) methods—miniaturization, parallelization and automation in particular—to carry out the large number of experiments required for th…
Article
Platform Technologies Improve Protein Expression
Sanofi is also pursuing process intensification for high-throughput, semi-continuous manufacturing in the short term.
Plasmid-Based Expression
Batavia Biosciences’ plasmid-based STEP technolog…
Article
Managing Residual Impurities During Downstream Processing
For DNA detection, Atouf notes that qPCR was included because it is by far the most commonly used technique in the industry due to its high sensitivity, specificity, dynamic range, high-throughput cap…
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HTPD: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…
Article
High Throughput Protein Purification at a Glance
In a blog post site manager Hanna Tegel and research engineers Anne-Sophie Svensson and Annelie Cajander, all from KTH – Royal Institute of Technology, Stockholm, share their knowledge about high-thro…
Article
Improving Process-Scale Chromatography
For example, Cytiva is currently using high-throughput screening techniques to screen hundreds of ligand designs with the goal of further improving process economy and robustness in mAb manufacturing …
Article
Generating a Fully Processed Antibody
At the time, a high-throughput detection method for FGE expression was not available; therefore, clones were selected based on the number of copies of the FGE gene that were inserted into the genome o…
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A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
This method can also be adapted to a 96-well plate for high-throughput media screening. Validation of the assay for quantitation of glucose in the culture media includes the demonstration of specifici…
Article
Modular Manufacturing Platforms for Biologics
May 01, 2015
By Randi Hernandez
BioPharm International
Volume 28, Issue 5
It should come as no surprise that the good design principles governing the execution of pharmaceutical manu…