Search results for "Upstream" in Articles / App Notes
Article
Process Development: 2020 Reflections and 2021 Possibilities
Bioprocess Development Forum readers also focused on upstream predictability and how companies are exploring process intensification efforts at every stage of upstream processing, which drives improve…
Article
Cytiva Introduces the Xcellerex Automated Perfusion System
16, 2020 that it is launching the Xcellerex Automated Perfusion System (APS), a device aimed at simplifying processes and reducing risks when intensifying upstream operations.
Integrated with Cyti…
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Next Generation Bioprocesses: Mapping Roads to the Future
So what are next-generation processes?
These processes overarch the whole manufacturing chain—from cell to molecule and upstream to downstream. They include semi-continuous and continuous approach…
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Moving PAT from Concept to Reality
Upstream focus
Most PAT tools that find wide use today are designed for application in upstream processes. “This focus is in large part due to the fact that initial protein quality and effectivene…
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Achieving Process Balance with Perfusion Bioreactors
The goal, according to Levison, is to intensify the process and reduce overall upstream process time, which delivers even more cost and time savings.
Ensuring process stability
The longer proc…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
For example, our studies have shown rather consistent incremental increases in upstream cell culture titers over the past three decades; and it took well over a decade for single-use equipment to atta…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
“Multiple steps are involved in upstream (e.g., seed train, infection/transfection, harvest), downstream (e.g., cell lysis, chromatography, filtration, and formulation), and fill/finish (e.g., filling…
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Future-proof your AAV process with a complete producer cell line – just induce and grow
…scaling to large-scale stirred tank bioreactors
• Learn how Cytiva can help you optimize your upstream processing — with cells, media, bioreactors, and filters that work in tandem
Watch the…
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Accelerating time to market through process innovation
Topics include:
- Next generation upstream process enablers
- Developing continuous downstream processing
- Aseptic filling
View the agenda and register here
Article
What is process development?
Bioprocess development is often divided into upstream process development and downstream process development. Those activities must be combined with the right analytics, so you can accurately measure …