Search results for "expression"
Article
Modular Manufacturing Platforms for Biologics
The work with G-CON through Caliber’s
Nicotiana benthamiana plant expression system “shows that podified downstream processing structures can be deployed and redeployed rapidly without compromisin…
Article
Detecting Protein Aggregates and Evaluating their Immunogenicity
Protein aggregation can occur during all stages of the lifetime of a protein therapeutic, including expression, refolding, purification, sterilization, shipping, storage, and delivery processes (1). T…
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Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors review efforts to limit polymer degradation without significantly impeding cell growth.
Jan 01, 2015
By Sara Ullsten, Shujian Yi, Jeffrey Carter, Eva Lindskog, Pokon Ganguli, Her…
Article
Mechanistic Modeling: Does it Have a Future in Process Development?
We were a bit anxious as to how they would receive a mathematical expression as a design space instead of a set of parameter ranges, which you typically get from a DoE set-up. To our surprise, they ac…
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Optimizing Resin Performance with Disposable Chromatography Solutions
Although the initial uptake of single-use chromatography solutions has been relatively slow, an increased need for higher-capacity resins and the demand for smaller batches has made disposable chrom…
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High-Throughput Process Development in an Historical Environment
Presentations, discussions, and information-sharing on modern bioprocess technology and high-throughput process development (HTPD) in an historical and culturally enriched environment is the essence…
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Biopharma Takes a Nervous Glance Over Its Shoulder
Changes are needed to maintain US biopharma innovation leadership.
The US biopharmaceutical industry’s status as the global leader in innovative biopharmaceutical R&D is not guaranteed. Both…
Article
Determining Criticality–Process Parameters and Quality Attributes Part III: Process Control Strategies—Criticality throughout the Lifecycle
These mathematical expressions can be represented graphically as either contour or 3-D response surface plots.
Even this view of the design space is too simplistic. To ensure a process has a…
Article
Best Practices in Adopting Single-Use Systems
Bioprocessors must first analyze benefits and risks for their specific situation, keeping in mind their expression system, process, product, and corporate objectives.
After determining the suitabil…
Article
Trends in Downstream Bioprocessing
• Expression systems are producing 5 times what they were 10 years ago.
• Current downstream/purification areas were not designed to handle this increase in production.
• Buffer capacity, colu…