Search results for "purification" in Articles / App Notes
Article
Techniques for Improving Process Development for Exosome-Derived Therapeutics
One can move to the next level of sophistication by changing the surface of the exosomes, in which case one might convert that first process into a platform that can be tweaked to effect adequate puri…
Article
Managing Residual Impurities During Downstream Processing
Host-cell DNA will also be present and must be minimized by the purification process. Elemental impurities can be present as well. There is, however, no set of standard assays for the determination of…
Article
Improvements in Protein A Chromatography
What are your key take-aways after this study on the evolution of Protein A chromatography?
Many people talk about replacing protein A chromatography step with alternative purification methods d…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Ion-exchange chromatography (IEC) is a major workhorse for purification of biotherapeutics. Development of a mechanistic model requires three major steps: modeling of mass transfer, modeling of bindin…
Article
Accelerated flavivirus vaccine production with modern tools and solutions
Single-use production bioreactors and chromatography purification columnsmitigate cross-contamination risk and support increased operator safety, while reducing time to market by eliminating costly an…
Article
Evaluating E&L Studies for Single-Use Systems
…ting the different skids separately, according to the worst-case in-use conditions of each specific purification step, following the risk assessment. Extractables studies on the chromatographic resin…
Article
How to Optimize Protein Desalting
Most protein purification workflows require desalting, buffer exchange, or both at one or more steps. But how do you determine which method to use? And how do you choose the right product for your n…
Article
Simplify chromatography method creation
Method creation is an essential part of preparing for automated protein purification runs. To save time and effort, method creation can be simplified and you can get to the point where you can start…
Article
Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
Purification can be in the order of several thousand-fold and recoveries of active material are generally very high.
This volume of the Affinity Handbook describes the role of AC in the purificati…
Article
Connect Alias™ Autosampler to ÄKTA™ Pure or ÄKTA Avant
When working with a large number of small volume samples, sample injection into your protein purification system can be tedious and time consuming. To minimize manual injections and save time, an auto…