Search results for "purification"
Article
Fortem: One Film for Single-Use Bioprocessing
Single-use bags can now be found at every stage of bioprocessing: bioreactor and mixing systems, harvest and collection, purification, and liquid and powder storage and transportation. Thus, Cytiva ha…
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Mapping a Route for Cell and Gene Therapy Process Development
The expansion process step is followed by clarification, purification, and final sterilization steps. The additional steps aim to increase the quality of the product, but may also reduce the quantity,…
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Risk Assessment: Studying Chromatography Resin Variability
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Many factors can give rise to process variability, such as variation in different process parameters or raw materials. This article focuses on process robu…
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Fundamentals of Hydrophobic Interaction Chromatography
This article explores the fundamentals and applications of hydrophobic interaction chromatography using Capto™ resins to increase productivity.
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Overcome Chromatography Challenges with Fiber Adsorbents
Bioprocessing evolution highlights the desire for new purification technologies that offer greater flexibility for use—from research and early process development through large-scale commercial prod…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
Cell therapy production does not have the numerous purification steps and analytical tests that are standard to mAb production.
To be able to scale up viral vector manufacturing, bioreactors—wit…
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Addressing the Complex Nature of Downstream Processing with QbD
In one case, we had an engineered antibody, which possessed properties that were not entirely amenable to our platform purification process.”
The company developed a new platform process for these…
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Moving PAT from Concept to Reality
…uence variants; nanotechnology-based analysis of charge heterogeneity that does not require protein purification; aptamer-based biosensors for N-glycosylation evaluation; next-generation sequencing (…
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Fiber-Based Protein A Chromatography for HTPD
Many analyses require purified proteins, and often substantial hands-on time is required for purification. The novel cellulose fiber technology (known as Fibro) may be used with ÄKTA™ chromatogra…
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How To Interpret Protein Binding Capacity: Chromatography Resins
The comparison between protein binding capacities of resin from different suppliers is not always straightforward. Different methods may have to be used, and often these methods are not stated direc…