Search results for "purification"
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Report from the 12th Plasma Product Biotechnology Forum
The model output was a prediction of yield and purification rate, and the input included feed flowrate, conductivity, column loading, and total protein concentration. One of the conclusions from the s…
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Create Digital Twins of your Chromatography Processes
The benefit of a mechanistic model? You can test thousands of purification options in a few hours.
GoSilico™ Chromatography Modeling Software creates digital twins of downstream processes usin…
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Good Modeling Practice
How to ensure accurate model calibration for your mechanistic models.
Mechanistic models have become a very promising technique to describe chromatography processes. These models …
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How to optimize AAV capsid separation
In this free, interactive course you’ll learn how to tackle one of the key challenges in Adeno-associated virus (AAV) manufacturing–separating full and empty capsids in the polishing step. You’ll …
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Approaches to scaling up Chromatography Processes
Scaling up chromatography resins requires a thorough understanding of their intended use.
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Alkaline stability of Fc and VH3 binding in protein A resins
In the development of antibody purification protocols, you need to know your Ab molecule and its possible affinity binding sites for the chromatography resins. In this study, we have looked at…
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New to mRNA manufacturing? Here's what you need to know
Click above for an in-depth guide on mRNA manufacturing.
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Top Process Development Trends for 2021 and a Look into 2022
But many challenges are associated with the process development for the downstream purification of these molecules.
Peter Guterstam, Ph.D., product manager of next generation resins & technologies …
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Maximum Output Starts with Optimized Upstream Processing
…processing capacity: continuous manufacturing, process analytics, and radically improved downstream purification. “There is a real shift,” agrees Chilima, “towards intensified technologies that enabl…
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How Do I Fix Asymmetrical Chromatography Peaks?
All good chromatography books say that the peaks in the chromatogram should be symmetrical, but what about real life in the lab? There are many different causes to “fronting” or “tailing” peaks, but…