Search results for "purification"
Article
Techniques for Improving Process Development for Exosome-Derived Therapeutics
One can move to the next level of sophistication by changing the surface of the exosomes, in which case one might convert that first process into a platform that can be tweaked to effect adequate puri…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
A cation exchange (CIEX) chromatographic step was developed as part of a collaborative project, where expertise in the field of downstream purification and bioprocessing was combined with specific bio…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
However, many of the protein-based chromatography resins used in purification of biomolecules are sensitive to harsh sanitization conditions. In this application note, the effects of treating MabSelec…
Article
Managing Residual Impurities During Downstream Processing
Host-cell DNA will also be present and must be minimized by the purification process. Elemental impurities can be present as well. There is, however, no set of standard assays for the determination of…
Article
Improvements in Protein A Chromatography
What are your key take-aways after this study on the evolution of Protein A chromatography?
Many people talk about replacing protein A chromatography step with alternative purification methods d…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Ion-exchange chromatography (IEC) is a major workhorse for purification of biotherapeutics. Development of a mechanistic model requires three major steps: modeling of mass transfer, modeling of bindin…
Article
Accelerated flavivirus vaccine production with modern tools and solutions
Single-use production bioreactors and chromatography purification columnsmitigate cross-contamination risk and support increased operator safety, while reducing time to market by eliminating costly an…
Article
Evaluating E&L Studies for Single-Use Systems
…ting the different skids separately, according to the worst-case in-use conditions of each specific purification step, following the risk assessment. Extractables studies on the chromatographic resin…
Article
How to Optimize Protein Desalting
Most protein purification workflows require desalting, buffer exchange, or both at one or more steps. But how do you determine which method to use? And how do you choose the right product for your n…
Article
Simplify chromatography method creation
Method creation is an essential part of preparing for automated protein purification runs. To save time and effort, method creation can be simplified and you can get to the point where you can start…