Search results for "purification"
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Challener
Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence of serum, culture harvest viability, turbidity, cell lysis r…
Article
Future Downstream Process Development Solutions for Advanced Therapies
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Q&As with Industry Leaders
mRNA manufacturing strategies
Manufacturing of viral vectors
Purification of plasmids
Oligonucleotide therapeutics
Article
Guide to Polishing Chromatography in Process Development
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This article shares the factors you should consider when developing your polishing steps—from the basics to the typical challenges faced, and how to overcome them.
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Article
Understanding Protein Production from Start to Finish
Most scientists working with exploring proteins and developing specific target biomolecules use several steps including cell culture, sample preparation, purification, and analysis. This requires unde…
Article
What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?
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In this study, the potential of Protein A chromatography to separate antibody monomer from HMW species was investigated. A design of experiments approach…
Article
Process Development: 2020 Reflections and 2021 Possibilities
Speaking of game changers, Fibro chromatography, a recently launched chromatography platform, has been shown to enable purification cycles in minutes instead of hours. This results in higher throughpu…
Article
Connected, Automated Downstream Process for mAb Screening and Evaluation
This study was done to show both proof of principle for an automation solution for a lab-scale protein purification set-up, and that it would significantly decrease hands-on time, while assuring that …
Resource
Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
Productivity, throughput, buffer consumption, and purification performance will be compared to traditional Protein A column chromatography.
Article
Improving Upstream Predictability
Some of the latest biopharmaceutical manufacturing facility designs have cell culture and some purification unit operations take place in one location, notes Mohindra.
At the same time, the …
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
Process qualification: All purification/isolation and processing steps should be optimized for target cell type.
Scale-up/scale-out:Stability studies and cryopreservation/biopreservation meth…