Search results for " fluid" in Articles / App Notes
Article
Platform Approach Speeds Process Development
Sophisticated tools, such as computational fluid dynamics, enable the characterization of cell-culture vessels with total volumes ranging from 250 mL to 12,000 L (Figure 4).
Figure 4: Depicti…
Article
CMOs Concerned With Cost of Single-Use Equipment
Other common pain points for both groups include material incompatibility with process fluids, single-source issues, and the high cost of disposables, with each of these a factor in restricting adopti…
Article
Re-use of Protein A Resin: Fouling and Economics
Proteases in harvested cell culture fluid are known to be responsible for proteolytic cleavage of Protein A ligand into fragments ranging in molecular weight from six to 40 kDa (27). Protein A ligand …
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
Disposable bioprocessing containers, such as those used for fluid storage or as bioreactor bags, are usually made from multilayer films. Typical resins used in multilayer films include, but are not li…
Article
A Q&A With Dr. Anurag Rathore About the Future of QbD, Part I
Examples of such tools include high throughput process development, computational fluid dynamics, and use of advanced statistical approaches for designing experiments, analyzing data, and process cont…
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
It then reproduces and builds up in the white (allantoic fluid) of the egg, which is collected and purified. It takes two eggs to generate enough vaccine for one dose, and thus large numbers of eggs m…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
As a consequence, downstream processing must accept and handle higher titers of mAbs in harvested cell-culture fluid (HCCF), and vendors of mAb purification technologies must develop chromatography re…
Article
The use of Xcellerex™ mixing system as slurry tank when packing chromatography columns
Introduction
Xcellerex XDM Quad Mixing System is designed for convenient and efficient mixing of buffer, media, product, and other process fluids (Fig 1). The single-use system eliminates the hass…