Search results for " expression" in Articles / App Notes
Article
Robust Optimization, Simulation, and Effective Design Space
The simulation includes three key sources of variation: the mathematical expression or model from the characterized product or process; variation of each factor at the targeted set point; and the resi…
Article
Host-Cell Protein Measurement and Control
Data indicate that different upstream processes only change the expression/secretion of a very small subgroup of HCPs within thousands of proteins (18). Using either platform HCP ELISA or process-spec…
Article
A Bright Future for the Plasma Fractionation Industry
There is still a very bright future for the plasma fractionation industry. That was one of the conclusions reached when the 9th Plasma Product Biotechnology (PPB) meeting ended on the beautiful isla…
Article
Modular Manufacturing Platforms for Biologics
The work with G-CON through Caliber’s
Nicotiana benthamiana plant expression system “shows that podified downstream processing structures can be deployed and redeployed rapidly without compromisin…
Article
Detecting Protein Aggregates and Evaluating their Immunogenicity
Protein aggregation can occur during all stages of the lifetime of a protein therapeutic, including expression, refolding, purification, sterilization, shipping, storage, and delivery processes (1). T…
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors review efforts to limit polymer degradation without significantly impeding cell growth.
Jan 01, 2015
By Sara Ullsten, Shujian Yi, Jeffrey Carter, Eva Lindskog, Pokon Ganguli, Her…
Article
Mechanistic Modeling: Does it Have a Future in Process Development?
We were a bit anxious as to how they would receive a mathematical expression as a design space instead of a set of parameter ranges, which you typically get from a DoE set-up. To our surprise, they ac…
Article
Optimizing Resin Performance with Disposable Chromatography Solutions
Although the initial uptake of single-use chromatography solutions has been relatively slow, an increased need for higher-capacity resins and the demand for smaller batches has made disposable chrom…
Article
High-Throughput Process Development in an Historical Environment
Presentations, discussions, and information-sharing on modern bioprocess technology and high-throughput process development (HTPD) in an historical and culturally enriched environment is the essence…
Article
Biopharma Takes a Nervous Glance Over Its Shoulder
Changes are needed to maintain US biopharma innovation leadership.
The US biopharmaceutical industry’s status as the global leader in innovative biopharmaceutical R&D is not guaranteed. Both…