Search results for " expression"
Article
Innovative Chromatography Resins Can Improve Purity and Quality
By: Feliza Mirasol
Recent innovations in chromatography resins offer promising advantages in downstream bioprocessing.
With ongoing efforts to increase monoclonal antibody (mAb) productivi…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
But are innovations sufficient to increase adoption? CMOs are demanding better continuous bioprocessing options. …
Article
The Need for Advanced Process Modeling for New Therapeutic Biologics
Early on, the process sequence and technologies can be changed, including cell lines and expression systems. By the time we are in production, however, these are fixed. Therefore, to fully optimize th…
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
Cell subset composition, cell phenotype expression, and the presence of inflammatory or stress-related factors can all impact target cell health, function, yield, and downstream therapeutic potency. …
Article
Biosimilar Quality Requirements
Factors to consider include the expression system, the manufacturing process, physicochemical properties, functional activities, target binding, impurities, the reference product and reference standar…
Poster
A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
Adenovirus (AdV) vectors are commonly used in cancer gene therapy trials and evaluated for use in vaccines for various diseases. In this study, we have combined technical evaluation of process steps a…
Article
What’s New in Upstream Technologies
Bench-scale automated cell culture system
The scale-X carbo, from Univercells, is a bench-scale automated cell culture system for the expression and concentration of viral drug substance suited fo…
Article
Successfully Moving Regulated Data to the Cloud
In light of recent FDA guidance on data integrity, the challenges and benefits of using the public cloud to deploy and use data management software are discussed.
By Stuart Ward
…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
This could be attributed to differences in expression system, culture conditions, purification processes, formulations, or storage conditions of the product and need to be suitably addressed as per th…
Article
Modeling the Degradation of mAb Therapeutics
They result in instabilities that can occur at various stages of product development, including upstream processing (during protein expression in cell culture), downstream processing (purification), p…