Search results for " expression"
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Optimizing Late-Stage and Commercial Cell-Culture Processes
Beyond that, Racher says, there is increased incorporation of synthetic biology paradigms into Chinese hamster ovary (CHO)-based expression platforms, moving the industry beyond simply increased titer…
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Preclinical Evaluation of Product Related Impurities and Variants
Further, under the quality-by-design (QbD) paradigm, gene expression from the neutrophils isolated from the treated animal groups would offer us an understanding of any deviations from the usual signa…
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ADC Development Robust Despite Lackluster Performance
ADC Development Robust Despite Lackluster Performance
Despite the disappointing therapeutic performance of ADCs thus far, the pipeline still boasts promising prospects.
By Feliza…
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Framing Biopharma Success in 2016
Corporate restructurings, regulatory initiatives, and biosimilars will shape biopharma development in 2016.
By Rita C. Peters
The US biopharmaceutical industry turned a new page in 2015 when…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Process development for chemistry, manufacturing, and controls (CMC) (15) includes selection of a cell line for protein expression, development of the culture process, and purification of the drug sub…
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Technologies and Practices Must Evolve to Meet Demand
Purification, stability, scale up, and achieving adequate expression levels of product were the top challenges identified by manufacturers of nucleic-acid based drugs in the 2015 survey, similar to th…
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Challenges of Protein Aggregation During Purification
Cytiva recently announced a licensing agreement with Promosome, a company with a technology for improved protein expression in mammalian cells. “We have hope that Promosome’s technology will be a bett…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
He also notes that adherent expression systems generally rely on serum-containing media formulations, and animal-derived components pose an additional risk for the introduction of adventitious agents …
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Design Considerations for a Commercial Cell and Gene Therapy Facility
“Getting these conditions just right requires balancing the cell line, expression system, media and growth factors, and bioreactor conditions—such as stir rate and gas transfer. For biologics and vira…
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The Outlook for CMO Outsourcing in 2019
microbial expression systems. The historical picture of respondents to the annual BioPlan survey reporting that they do not outsource bioproduction is shown in Figure 1.
Figure 1: Biopharmaceut…