Search results for " separation" in Articles / App Notes
Article
Considerations in depth filter scale-up
Depth filters are widely used in the biopharmaceutical industry. They are typically made of a mixture of cellulose, filter aids, and a binder. These components can be milled and mixed in diffe…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Sterility must be assured for all biologic drug products. Terminal sterilization achieved via treatment with heat, radiation, or certain chemicals (vaporous hydrogen peroxide, vaporous peracet…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
We demonstrate a scalable workflow for the isolation of exosomes—a type of extracellular vesicle with significant potential for targeted drug/gene delivery. For research and development and di…
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Paring Down Impurities in Downstream Processing
All of these lead to a gamut of membrane separation, centrifugation, extraction, precipitation, and chromatography technologies. Biology and financial costs then ultimately dictate what works best for…
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Selecting Chromatography Resins for Bispecific Antibody Purification
Advances in chromatography resins are helping to simplify downstream operations and improve separation performance.
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Get Started: Purification of mAb Variants - eLearning
The success of monoclonal antibodies (mAbs) as therapeutics and the multi-domain structure of antibodies has made it possible to create antibody variants, such as bispecific antibodies (bsAbs)…
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Chromatography innovations for the diversified antibody pipeline
Our MabSelect™ VH3 affinity resin interacts with the variable heavy chain of the VH3 sequence family of human antibody, delivering high binding capacity and efficient separation of product-related imp…
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
Join this webinar to:
• Learn how to optimize affinity capture
• Discover critical parameters that enhance full and empty capsid separation
• See polishing data for several rAAV serotypes
…
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Report from the 6th International HTPD Conference
Calculated descriptors for proteins and resins could then provide predictions of product binding and optimal screening regions for separation. This QSAR models were followed by the mechanistic modelin…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Development beyond traditional monoclonal antibodies (mAbs) is increasing, and today, we see antibody variants like multispecific and bispecific antibodies and antibody fragments. In mAb proc…