Search results for " separation" in Articles / App Notes
Article
Evolution of the Monoclonal Antibody Purification Platform
…action chromatography, thus offering a larger range of ionic strength and pH under which significant separation can occur (6,7).
Mixed-mode resins based on hydroxyapatite, made from calcium phosp…
Article
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
If we think of this as being a way of simulating chromatograms with the help of the computer, you take data related to your chromatography system, to your column, and to the separation that you're doi…
Article
Cell-free Expression Systems Pose Cell Culture Alternative
By producing less waste upstream, there is the potential benefit of having less burden downstream in the separation and purification steps. However, the practicality of using cell-free expression syst…
Article
Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.
By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani
Drug development is …
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
This might have an even bigger economic impact than quickly identifying optimal process conditions for an easy separation.
I also foresee that we will see the appearance of predictive mechanistic …
Article
Eliminating Residual Impurities Starts with a Strategic Plan
The chosen separation and detection technologies must also be suitable to the analysis without degradation of the impurities occurring.
Overall, potential process-related and other residual impu…
Article
Successfully Moving Regulated Data to the Cloud
Also associated with this is a clear separation of duties when using a cloud provider. The cloud works in a similar way to a laboratory environment, where you have a separation of duties between the u…
Article
Achieving Process Balance with Perfusion Bioreactors
Pall Biotech is working on adopting acoustic wave separation (AWS) technology, originally developed for batch applications, for perfusion processes. The company is gathering data at the process develo…
Article
Impurity Testing of Biologic Drug Products
Experts share insights on the various methods used for purity and impurity analysis of therapeutic proteins.
By Adeline Siew, PhD
CA-SSIS/shutterstock.comIm…
Article
Reducing Cross-Contamination Risks in Process Chromatography
In addition, single-use process chromatography tools are limited to low-pressure applications, and these tools typically cannot withstand the harsh chemicals used in reversed-phase chromatographic sep…