Search results for " separation" in Articles / App Notes

Article Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
A single-step downstream process using protein A chromatography to purify a bispecific antibody (BsAb) in early screening has been successfully developed to replace an existing three-step process. T…

Article Modeling the Degradation of mAb Therapeutics
Modeling the Degradation of mAb Therapeutics Kinetic models can be used to study aggregation and fragmentation to help ensure stability. By Anurag S. Rathore, Rohit Bansal …

Article Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions

Article The Challenge of Disruptive Technologies in Bioprocessing
“Achieving good capacity and separation under higher salt concentrations for added flexibility and process simplicity is important. A salt-tolerant resin can be beneficial to a purification process by…

Article Understanding Validation and Technical Transfer, Part 3
Understanding Validation and Technical Transfer, Part 3 Validation ensures safe and effective biologic products that benefit the patients whose health and wellbeing depend on the therapies. Part 1 |…

Article Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography Early adopters are benefiting from lower costs and increased productivity. By Cynthia A. Challener Tashatuvango/Shu…

Article Roadmap Leads to Innovative Biomanufacturing Strategies
Roadmap Leads to Innovative Biomanufacturing Strategies The Biomanufacturing Technology Roadmap is accelerating innovative manufacturing strategies for biopharmaceuticals. By Feli…

Article Connected Polishing and Concentration Under One Automation Method
Chromatography and tangential flow filtration (TFF) steps are traditionally performed as separate unit operations in downstream bioprocessing. This work aims to demonstrate the capability of the UNICO…

Article Handbook: Design of Experiments in Protein Production and Purification
In a protein research lab or during process development, a DoE approach can greatly improve the ef ciency in screening for suitable experimental conditions, for example, for cell culture, protein sepa…

Article Avoiding Investigational Failures and Discrepancies
Avoiding Investigational Failures and Discrepancies Investigational failures and discrepancies can be avoided through the proper execution and documentation of investigations. By Walt Murray,…

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