Search results for " continuous"
Article
Four Steps Toward End-to-End Connected Manufacturing
Reduce costs and increase efficiencies by implementing continuous biomanufacturing strategies into upcoming processes. Continuous biomanufacturing is a key step toward promoting drug quality and imp…
Article
Monitoring and Control of Inline Dilution Processes
Buffer management has received less attention in process intensification despite the high costs and labor-, space-, time-, and material-intensive nature of this common downstream activity.
By…
Article
Modeling the Degradation of mAb Therapeutics
The concentration of F2 species continuously increases throughout the study. On examining these observations, the following mechanism is proposed:
Moreover, this model was verified expe…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
The biopharmaceutical industry continues to expand in new and exciting ways. What might be in store for 2019, and what important lessons should process developers take from 2018? Here, we look back …
Article
Scaling Up Novel Therapies
…fusion on the upstream side, and multicolumn operations, whether it’s just higher cycling, or more continuous or semicontinuous chromatography (e.g., simulated moving bed (SMB) technologies), downstr…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
In addition, development of intensified processes and integrated continuous processing (with single-use technology and sensors/control) have also contributed to increasing titers, maintaining consiste…
Article
Biopharma Seeks Balance
…tive modeling for process monitoring and closed loop bioreactor control, next-generation sequencing, continuous manufacturing for downstream processes, and a manufacturing platform for continuous bio…
Article
Putting Viral Clearance Capabilities to the Test
On the other hand, the laboratory model viruses have a great chance of contaminating bioreactors using continuous cell lines.”
Gilljam identified other challenges. “Due to the volume tested in the…
Article
Leveraging Data for Better Biopharmaceutical Process Control
BioPharm: What is preventing a more unified approach to integrated continuous bioprocessing?
Gouveia: Several companies are working on end-to-end continuous biopharmaceutical processes, but th…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
Sodium citrate acts as critical component for continuous cell growth and upregulated recombinant protein production (7–10).
Sugars
Sugars are a major source of energy for the cells and also hel…