Search results for " system"
Article
Continuous Chromatography: Trends, Definitions and Approaches
As this movement is seen periodically, one could argue that the name Periodic Counter Current (PCC) is the most appropriate to describe what is really happening in a multicolumn system. However, for t…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Regardless of the indication or program, Kellerhals emphasizes that quality systems and regulations are universal and overarching, and adherence to strict quality standards is essential to ensure cons…
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Digitalization: The Route to Biopharma 4.0
Digitalization is fuelling the shift from paper-based records to digitalized central databases, making data storage and handling more systematic and efficient. This, in turn, facilitates knowledge tra…
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Automation Trend in Fill/Finish Reduces Contamination Risk
Because aseptic filling requires close coordination and involves complex interaction between personnel, sterilized product, the fill/finish equipment system, the cleanroom—including support facilities…
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Unifying Continuous Biomanufacturing Operations
The most efficient upstream processing systems in biologics manufacturing seek to mimic the body’s treatment of cells, so a constant level of incoming nutrients and outgoing waste products is necessar…
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Automating Bioprocesses
By Jennifer Markarian
Both upstream and downstream biopharmaceutical processes have conventionally used stainless-steel equipment, but use of single-use systems (SUS) is becoming more established.…
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Automating Processes in Upstream Processing
The process control system needs to be developed in a manner that is flexible enough to have different strategies enabled dependent on the product. An example might be different DO2 control strategies…
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A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
What developments with single-use systems were discussed?
There were several storylines about single-use systems at INTERPHEX. A number of equipment manufacturers announced new bioreactors, fermen…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
During this period of explosion in the application of CHO expression systems, considerable efforts have been made to improve recombinant protein production to meet the demands of high quantity and con…
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Antibody Production in Microbial Hosts
However, clinical success of mAbs has tremendously increased their demand, and this in turn has fueled interest in other cost-effective alternative production systems such as microbial hosts. Further,…