Search results for " manufacturing"
Article
Pharma Investments Reflect Key Industry Trends
“As a consequence, there is an opportunity to scale down biologics manufacturing, and newer facilities are typically based on 2000-L or smaller reactors and are much less cash-intensive, which is a ke…
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Gene Therapies Push Viral Vector Production
By now, a wide variety of AAV serotypes have been studied, adds Kai Touw, technical lead at Batavia Biosciences, a Netherlands-based contract development and manufacturing organization (CDMO). Some of…
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A Plastic Pipeline for Commercial Bioprocessing?
Pressure to get drugs to market faster, the smaller batch sizes characteristic of targeted therapies, and the comfort level biopharma companies and contract manufacturing organizations (CMOs) have wit…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
This article highlights some of the significant changes in biopharmaceutical manufacturing (bioprocessing) that have occurred from 2003 to 2018. Most all of the changes in bioprocessing that have occu…
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Biopharma Advances Demand Specialized Expertise
The approval of the first biosimilar in the United States, as well as continuing consolidation in the biopharma and contract development and manufacturing markets, are just two indicators of the ongoi…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
These advantages, according to Atul Mohindra, senior director of R&D for Lonza, drive down overall contamination rates as well as enhance the efficiency of a production facility while reducing manufac…
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Biopharma Seeks Balance
The strategic shift by small companies to focus on rare or orphan diseases that afflict smaller populations altered research and manufacturing processes and also changed business models. Big Pharma sp…
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Taking a “Development-by-Design” Approach to Cell Therapies
This has been traced to problems with manufacturing and failure to understand process requirements earlier in the development process. Table I outlines manufacturing issues.
As a growing number of…
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Biosimilars Development and Supply: How Complex Can the Process Be?
Developing a high-quality biologic medicine that is safe and effective also requires a commitment to manufacturing excellence. Innovator companies often need to invest up to $1.2 billion to bring a bi…
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Remote Monitoring and Big Data Advance Upstream Automation
Challener
As upstream processing drives toward higher efficiencies in meeting demand, it requires optimizing the current state of manufacturing with the goal of achieving real-time release and an …