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Article Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Therefore, the industry continues to seek solutions from innovators for better continuous processes that offer further process intensification and lower costs. In fact, 70.6% of bioprocessing professi…

Article Gene Therapies Push Viral Vector Production
“This makes it a popular starting point for gene therapy, although many serotypes continue to struggle with manufacturing challenges, such as low production yields and therefore high cost of goods,” T…

Article The Need for Advanced Process Modeling for New Therapeutic Biologics
…so means there is a need to develop a better or new understanding of workflows, whose efficiency and cost can be predicted through process modeling.   How modeling fits QbD Nearly all aspects…

Article Roadmap Leads to Innovative Biomanufacturing Strategies
Frohlich: The mapping process began with the identification of the major business drivers facing the biopharma industry: speed, flexibility, cost, and quality. The map then was designed to target thes…

Article Best Practices for Data Integrity
Many companies thus view data integrity as a law-mandated, paper-intensive, cost center. Stereotypes are changing, however, as innovative companies are leveraging technology to turn data integrity int…

Article Process Chromatography: Continuous Optimization
“By increasing the throughput, process flexibility, and process performance, the costs associated with purification can be decreased and more productive processes can be realized,” she states. Ion…

Article The New World of Biopharmaceutical Manufacturing
…leaning validation, and faster turnaround between products and batches, resulting in reduced capital costs and increased speed to market. Single-use technology has also precipitated changes in upstre…

Article Unifying Continuous Biomanufacturing Operations
As the concept of integration makes its way from theory to practice, manufacturers will have to carefully weigh the costs and benefits of using continuous methods for biologics. In the future, manufac…

Article Improvements in Protein A Chromatography
… about replacing protein A chromatography step with alternative purification methods due to the high cost, low capacity and limited robustness of Protein A. However since 1978, the capacity and produ…

Article Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
This includes single-use technology, which has been shown to reduce capital and operating costs by 40%-50%,1 and modular and flexible manufacturing systems, which are seen by many as a way for biophar…

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