Search results for " cost" in Articles / App Notes
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Cycle-time reduction
Single-use technology implementation in chromatography can greatly reduce cycle times, lower operating costs and energy consumption, and generate less waste, according to Young…
Article
Re-use of Protein A Resin: Fouling and Economics
In a typical platform process for production of mAb therapeutics, approximately 80% of the total process costs are for the steps following fermentation, with up to 60% of the downstream costs coming f…
Article
The Bullish Outlook for Biosimilars
Most importantly, a number of patents are set to expire on leading biologics, and financially strapped payers across the globe are anxious to embrace biosimilars and their promise of cost savings. Yet…
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Reimagining Affordable Biosimilars
While effective and successful, biotherapeutics are presently marred by their high costs, which make their affordability poor for most of the world and thereby limit their accessibility.
The adv…
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Technology Innovations Improve Process Chromatography Performance
“In downstream processing, the ultimate goal for biopharma manufacturers is to improve recovery and reduce the cost per gram of protein produced. Currently, over 60% of the cost to produce a new biolo…
Article
Monitoring and Control of Inline Dilution Processes
Buffer management has received less attention, despite the high costs and labor-, space-, time-, and material-intensive nature of this common downstream activity. Inline dilution (ILD) combined with i…
Article
A Plastic Pipeline for Commercial Bioprocessing?
Lower capital costs for facilities and equipment, lower operating costs, smaller equipment footprints, lower overhead costs, flexibility of system configurations, faster changeover times, the reductio…
Article
Perfusion in the 21st Century
Now, improved continuous culture technologies such as perfusion are on the rise, as biosimilar manufacturers look for new ways to cut costs while increasing quality and productivity.
With perfusio…
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Comparing Protein A Resins for Monoclonal Antibody Purification
In addition, more cost-efficient cleaning procedures are necessary to extend the lifetime of chromatography resins and to reduce the cost for cleaning and validation. A team from Chugai Pharmaceutical…
Article
Evolution of the Monoclonal Antibody Purification Platform
Though extremely efficient and effective, the step primarily suffers from the significantly high cost of Protein A resins in comparison to other popular modes of chromatography (such as ion exchange).…