Search results for " column"
Article
Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
To address those concerns, extractables studies were
performed on disposable chromatography column housings and disposable flow paths provided by Cytiva. The extractables studies were performed wi…
Article
Technology solutions simplifying chromatography unit operations
Chromatography operations typically involve steps such as resin slurry preparation, column packing, cleaning, unpacking, and resin storage. While each of the aforementioned steps can potentially be …
Article
Analysis of Glycosylation in Biosimilars
The interaction of the glycans with the column matrix depends on the overall structure of the glycans, not just their mass.
The various antennary structures give different retention times, and thu…
Article
Maximize resin usage with continuous bioprocessing
The technology employs three or more chromatography columns to create a continuous purification step. In a PCC setup, columns are switched between the loading and nonloading steps, such as wash and el…
Poster
Unlocking the potential for efficiency in downstream bioprocesses
It also shows how implementation of efficient process designs can overcome traditional downstream bottlenecks, such as time-consuming column packging, cleaning of equipment, and laborious buffer tank …
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
If chromatography columns are used in the process flow, also specify the column volume and diameter required along with the desired number of cycles for each step.
Many single-use consumable suppl…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
…uctures with their different reporter groups, because these have different elution times from the GC column. The combination of GC retention time and mass spectral fingerprint fragmentation pattern i…
Article
Selecting the Right Viral Clearance Technology
Riske adds that these problems generally arise because the column and purification conditions are chosen based on the ability to produce a purified protein that meets specifications and are developed …
Article
Single-Use and Continuous Processing Technologies Change Facility Design
With stainless steel, duplicate equipment is needed to prepare one column step offline for the next campaign. With SU, however, new equipment is put in place with little preparation required.
In t…
Article
Biopharma Moves to Integrated, Single-Use, Downstream Processing
“It is possible that customers do not perceive column packing as a pinch point (non-value-add point) in their manufacturing process (i.e., the problem is not big enough) or perceive a decrease in flex…