Search results for "concentration"
Article
Using Multiple Techniques in Biosimilar Analysis
Similarly, the formulation buffer may include excipients that cause some techniques to fail, or the formulation concentration of the API may be too low to detect using certain techniques. These occasi…
Article
Scaling Up Novel Therapies
“The key to exploiting this intensified upstream process is having downstream processing solutions that can handle the increase in mass and concentration of product and not become the process bottlene…
Article
The Challenge of Disruptive Technologies in Bioprocessing
“Achieving good capacity and separation under higher salt concentrations for added flexibility and process simplicity is important. A salt-tolerant resin can be beneficial to a purification process by…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
In Lonza’s experience, increases in viable cell concentration and maintaining high culture viability for longer duration have primarily contributed to productivity increases, rather than improvements …
Article
Biopharma Seeks Balance
Biopharma Seeks Balance
Biopharma companies can balance competing demands from patients, investors, and regulators by keeping a focus on science.
By Rita C. Peters
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Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
This article highlights 15 years of changes in biopharmaceutical manufacturing.
By Ronald A. Rader, Eric La…
Article
Putting Viral Clearance Capabilities to the Test
“Relevant viruses may be difficult or impossible to produce in high concentrations. Therefore, model viruses, preferably of the same genus or family, are used as substitutes,” says Gilljam.
“Even …
Article
Leveraging Data for Better Biopharmaceutical Process Control
However, the low concentrations and/or aqueous matrices involved created several challenges, particularly for NIR spectroscopy, due to a lack of sensitivity and specificity.
Monitoring calibrat…
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Making the Move to Continuous Chromatography
Some systems come with dynamic control functionality—process analytical technology (PAT)—that enables the continuous chromatography unit operation to better adapt to changes in feed concentration (whe…
Article
Impurity Testing of Biologic Drug Products
The commonly used analytical methods for characterizing these proteins include UV spectroscopy for concentration; SEC, analytical ultracentrifugation (AUC), and field flow fractionation (FFF) for aggr…