Search results for "antibodies" in Articles / App Notes

Article Platform Approach Speeds Process Development
By Harald Bradl, Jan Bechmann, Benedikt Greulich, Markus Michael Mueller, Patrick Schulz, Thomas Wucherpfennig Commercial production of complex biopharmaceuticals such as recombinant monoclonal an…

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
This early screening approach has identified cryptic aberrant splice sites in multiple therapeutic candidates including monoclonal antibodies, bispecific antibodies, and fusion proteins, therefore pre…

Article Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
By Anna Grönberg An important area of focus for the biopharma industry is the elucidation and development of robust, efficient, and economic purification strategies for new monoclonal antibodies (…

Article Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
Protein L resins bind to kappa light chain and are often used to purify antibody fragments such as dAbs and Fabs — but they can also be used to remove product-related impurities from bispecif…

Article Paring Down Impurities in Downstream Processing
Myriad choices confront manufacturers before they even consider optimizing downstream processes. Each decision directly influences what final options will be available on arriving at the final…

Article Digitalization: The Route to Biopharma 4.0
Side-by-side Comparability of Batch and Continuous Downstream for the Purification of Monoclonal Antibodies. Biotechnol. Bioeng. 2020, 117 (4), 1024–1036. 19. Fisher, A. C.; Kamga, M. H.; Agarab…

Article Western Blot Detection: Is Film or a Digital CCD Imager Better?
It is based on building an antibody:protein complex via specific binding of antibodies to proteins immobilized on a membrane and detecting the bound antibody with one of several detection methods. …

Article Scaling Up Novel Therapies
Used almost exclusively for monoclonal antibodies (mAbs), platforms help shorten development times, particularly early in development, Ransohoff says. They also allow manufacturers to leverage perform…

Article Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…

Article Unifying Continuous Biomanufacturing Operations
The company was granted a US patent in December 2016 for a portable, integrated, automated method for the manufacture of antibodies. Specifically, the patent describes the production of Synagis (paliv…

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