Search results for "antibodies"
Article
Elucidating Biosimilars Characterization
In addition, some proteins, for example, monoclonal antibodies, have half-lives of weeks. These proteins would, therefore, require sample collection for many weeks to accurately define the pharmacokin…
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Best Practices for Selecting a Top-Quality Cell Line
Before scaling up to bioreactors, the productivity level for monoclonal antibodies (mAbs) should be 2–7 g/L (fed-batch culture in shake flask) or greater, observes Selexis CEO Igor Fisch. Once scaled …
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Improving Process-Scale Chromatography
More than 40 years of improvement in Protein A chromatography has resulted in well-established, robust purification processes for monoclonal antibodies,” Ljungqvist concludes.
Specifically, multim…
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Analysis of Glycosylation in Biosimilars
The structures of protein drugs such as monoclonal antibodies are made more complex by post-translational modifications. The most notable of these is glycosylation, where carbohydrate residues are att…
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Implications of Cell Culture Conditions on Protein Glycosylation
Multi-chain proteins, such as IgG antibodies, additionally have a quaternary structure resulting from structural associations between the subunits.
The choice of host-cell line for recombinant pro…
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Ligand-Binding Assays and the Determination of Biosimilarity
For monoclonal antibodies (mAbs), which make up a large portion of the biosimilars currently under development, it is important to remember that the different ends of the molecule are involved in bind…
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Trends in BioPharma Approvals in 2013
Engineered antibodies
Genentech’s Gazyva represents another milestone in antibody approvals, being the first glycoengineered mAb to come on the market in the US. mAbs are glycoproteins, carrying a…
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ADC Development Robust Despite Lackluster Performance
The company has developed a pipeline of ADCs, as well as antibodies and human-derived proteins, that target the tumor-associated stroma. For its ADC development, the company is developing antibodies t…
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Patenting Prospects for Cell-Based Therapies
The history of biomedical advances over the past 50 years has focused predominantly of increasing complexity, from small-molecule therapeutics to antibodies, cytokines, blood-clotting factors, and pro…
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Biopharma in 2015: A Year for Approvals and Innovations
…dic Counter-Current Chromatography
Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
Trends in Single-use Bioreactors
Process economy and production capacity using sin…