Search results for " purity"
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Accelerated flavivirus vaccine production with modern tools and solutions
This white paper includes a Fast Trak Services case study on the use of such resins to increase purity and yield of a flavivirus vaccine manufacturing process.
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Simplify Every Step of Histidine-Tagged Protein Purification
A purity between 60% and 80% was achieved when using a manual purification workflow. To improve this, an automated purification approach was evaluated. Learn more in this blog post how automated his…
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Efficient Purification of the Pertussis Antigens Toxin, Filamentous Haemagglutinin, and Pertactin in Chromatography Workflows
The described method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.
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A Platform Approach to Purification of Antibody Fragments
The described BioProcess™ resins offer high selectivity and excellent pressure-flow properties for high purity and yield in industrial-scale purifications. In addition, several case studies on purific…
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Analysis of Glycosylation in Biosimilars
Monosaccharide analysis can also give a purity check: high levels of glucose might suggest the breakdown of Sephadex beads, for example, in the purification process, and high mannose levels may indica…
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Design and Qualification of Single-Use Systems
The author provides a review of the concepts of design and qualification that apply to single-use systems.
By Jerold M. Martin
Single-use technologies (SUT) have made significant inroads in …
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An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Chemically defined raw materials have all components identified; components are in the chemical form, and the structure and concentration of all components is known and of high purity with only minima…
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Going Small to Achieve Success on the Commercial Scale
“Demonstration of both individual unit and linked unit output (recovery, product quality attributes, product purity, chromatographic profiles/transition analysis, etc.) comparability between small and…
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Selecting the Right Viral Clearance Technology
…on the ability to produce a purified protein that meets specifications and are developed to maximize purity with reasonable recovery. Only then is a chromatography step tested for viral clearance. “O…
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Best Practices in Qualification of Single-Use Systems
To ensure the drug product quality and patient safety, the SUS shall not be reactive, additive, or absorptive so as to alter the safety, identity, strength, quality, or purity of the drug product (11)…