Search results for " therapeutic" in Articles / App Notes
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
By Mark Plavsic
Use of continuous cell lines in the manufacture of biological therapeutic products, such as vaccines, recombinant proteins, and monoclonal antibodies, is associated with the concom…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
…cies of the trypsinization technique and help realize the huge potential of adherent cells to enable therapeutic and diagnostic solutions.
Cell attachment requires the interaction of cell membran…
Article
mAbs to Watch in 2016
Obiltoxaximab—Elusys Therapeutics’ mAb, obiltoxaximab, which will go by the trade name Anthim, differs significantly from the rest of the mAb pack. The investigational agent for the treatment of inhal…
Article
Taking a “Development-by-Design” Approach to Cell Therapies
… successfully completed projects in North America, Europe, and Asia for companies that include Argos Therapeutics, Aastrom, CCRM, Humacyte, Innovacell, Janssen, kSep Systems, MolMed, Organovo, and Vi…
Article
Use of Multivariate Data Analysis in Bioprocessing
MVDA applications in cell-culture operations
Cell-culture operations are by far the most common platform used for production of protein therapeutics. In this endeavor, various advanced offline and…
Article
Fermentation for the Future
…rains that it can screen using high-throughput technology to identify the optimal choice for a given therapeutic protein. These strains do not form IBs and produce the protein in the periplasm, from …
Article
Q&A with Industry Leader Konstantin Konstantinov, Genzyme Vice-President
In addition, continuous processing offers biotechnology companies increased flexibility—you can use the same platform for various types of therapeutic proteins. More flexible management of manufacturi…
Article
Biosimilars Development and Supply: How Complex Can the Process Be?
High-quality, reliably supplied biosimilars offer additional therapeutic choices to patients and other key stakeholders; however, development and supply of these complex medicines are scientifically c…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
The platform was developed to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies. The success of this p…
Article
Optimizing KiH bispecific antibody chromatography steps
Bispecific antibodies (bsAbs) are a promising class of therapeutic agents due to their ability to bind to two different types of antigens or two different epitopes on the same antigen. This a…