Search results for " scalability" in Articles / App Notes
Article
Witnessing Major Growth in Next-Generation Antibodies
It is necessary, he adds, to be able to show both scalability and manufacturability, particularly that these products can be produced in large quantities with relative ease in order to meet the treatm…
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Improving Process-Scale Chromatography
Both Cytiva and Pall have systems based on countercurrent processing and are collaborating with customers to demonstrate the scalability of their technologies.
Developments from Cytiva include the…
Article
Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
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Continuous Processing for the Production of Biopharmaceuticals
The significant benefits that continuous processing offers—including higher profitability, ease of scalability, and lower manufacturing footprint—make this a topic of interest to every biomanufacturer…
Article
Selecting the Right Viral Clearance Technology
By Cynthia Challener, PhD
The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug production that is well addressed by international regulatory requirements…
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Antibody Fragments and Their Purification by Protein L Affinity Chromatography
Antibodies and related proteins comprise one of the largest and fastest-growing classes of protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however, many new entities…
Article
Fermentation for the Future
Improving efficiency, value chain, quality, and protein complexity with advanced bioprocess development.
Jan 01, 2015
By Cynthia Challener, PhD
Microorganisms—bacteria and yeast—have b…
Article
Ligand-Binding Assays and the Determination of Biosimilarity
Matthew Reuter, biotherapeutics business development with PerkinElmer, adds, “These novel nonradiometric homogenous no-wash platforms aid in assay transferability, reproducibility, scalability, and ov…
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Optimizing Resin Performance with Disposable Chromatography Solutions
They appreciate the convenience, flexibility, and scalability that they offer, and in the case of OPUS, the ability to pack any media at any bed height. We are definitely seeing growth as well as dema…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
To test the scalability as well as to remove the negative effects from the high pH feed media, 7-L bioreactors were used to run cell line A process with pH control. The profiles of viable cell density…