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Article Scalable Viral Vector Manufacturing
The manufacturing processes and technologies are critical to enable cost-efficient and scalable production of safe and efficacious clinical-grade virus products. This week, Process Development Forum s…

Article Virus-like Particles as Therapeutic Moieties of the Future
Rathore Virus-like particles (VLPs) are viral capsid shells assembled without encapsulated nucleic acid. These particles resemble native virions, are highly ordered and repetitive, and are approxi…

Article From Darwin to Recombinant Fc Multimers
In the session, Nathan Roth from CSL Behring Australia presented approaches towards Hepatitis E virus and Zika virus, two recent emerging pathogens, and studies confirming the effectiveness of existin…

Article Ensuring the Biological Integrity of Raw Materials
(4) One affected vaccine was Rotarix, a rotavirus vaccine manufactured by GlaxoSmithKline. Porcine circovirus was detected in the vaccine, a discovery that led to a halt in the use of Rotarix, which i…

Article Selecting a Comprehensive Bioburden Reduction Plan
For example, mammalian cell lines or formulation constituents may require routine monitoring for mycoplasma or viruses. Open process operations are more susceptible to contamination than are closed pr…

Article The Development and Application of a Monoclonal Antibody Purification Platform
The eluate was then held at this low pH to inactivate viruses, and then adjusted to increase the pH before the cation exchange chromatography step. After cation exchange, diafiltration was perf…

Article Single-Use Technologies Prove Effective for Viral Vector Process Development
Notably for the manufacture of vectors based on adeno-associated virus (AAV), one of the most common vector types for gene therapy delivery and viral-vector vaccines, recent data have shown that stain…

Article Vaccine Development Faces Urgency and Challenges
By Jill Wechsler The Ebola outbreak in 2015 and the current stampede to develop a new vaccine to combat the Zika virus illustrate the increasingly important role of vaccines in advancing public he…

Article Report from the Eighth International Plasma Product Biotechnology Meeting Melia Salinas, Lanzarote, Spain
…ays and possible also implementing heat treatment to the relevant plasma products to inactivate the virus. In the Pathogen Safety session an illustrative presentation was given by Jun Adan-Kubo from …

Article A Look at the Affinity Chromatography Landscape
Another option is the use of monolithic, convective chromatography supports, which are widely used for the purification of macromolecules such as viruses, virus-like particles, plasmid DNA, and cells.…

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