Search results for " Downstream PD"
Article
Create Digital Twins of your Chromatography Processes
Mechanistic models make it possible to create computer simulations of chromatograms. The simulations, are based on physiochemical phenomena known to occur in chromatography. The benefit of a …
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Top Process Development Trends for 2021 and a Look into 2022
The COVID-19 pandemic continues to shape bioprocess development trends, and many lessons have been learned from industry’s response to and preparedness for dealing with a public health crisis. Howev…
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Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator Bioscience AB develops antibody-based pharmaceuticals for cancer treatment, specializing in mono- and bispecific antibodies for tumor-directed immunotherapies. Alligator and Cytiva devel…
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Maximum Output Starts with Optimized Upstream Processing
By Cynthia A. Challener
Biopharmaceutical companies and contract manufacturers respond to changing demand dynamics for upstream bioprocessing capacity.
Significant growth in the develo…
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Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
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Common Challenges in Cross-Functional Process Development
cross functional
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James Blackwell, President, Windshire Group, LLC, explores common challenges in cross-functional process developme…
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Basics in Process Development for Biotherapeutics
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Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.
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Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
The new Protein A fiber chromatography format allows for quick purification of many samples because of its short cycle times. This makes the pre-packed, small-scale Protein A fiber unit a versatile …
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High-Throughput Process Development in Biopharma
Efficient development of the manufacturing process is a crucial component of overall biopharmaceutical development. During early process development, high-throughput process development (HTPD):
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Improving Upstream Predictability
Better understanding and control of cell behavior is yielding benefits, upstream and beyond.
By Agnes Shanley
In the earliest days of biotech, developers often struggled to sust…